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Drew Brees has further solidified his legacy as one of the most prolific passers in NFL history. During the Saints "Monday Night Football" game against the visiting Colts, the 20-year veteran broke Peyton Manning's record for career touchdown passes during the third quarter with a five-yard strike to tight end Josh Hill to give the Saints a 27-0 lead over the Colts. 

He tied the mark in the second quarter on 21-yard score to Tre'Quan Smith.

Brees, who needed three touchdowns entering the game to pass Manning, now has 541 career touchdown passes (he hit Taysom Hill for a score in the third quarter, marking his 21st straight completion in the game) and counting, passing Manning's 539.e